Alkaline Phosphatase-Controllable and Red Light-Activated RNA Modification Approach for Precise Tumor Suppression. We explain the importance of establishing these indicators for application in rural China and other developing countries as a complement to the World Health Organization's reproductive health indicators for global monitoring present the identified indicators and describe lessons learned from field testing in low-, middle-, and high-income counties of China's countryside. Jing Fang, Yali Feng, Yuqi Zhang, Anna Wang, Jiachen Li, Chaoxiang Cui, Yirui Guo, Jinfeng Zhu, Zhengzhong Lv, Zhongsheng Zhao, Chenjie Xu, Haibin Shi. Major criteria for the indicators were practicality, feasibility, and measurability within China's rural areas. Nominal group process entailed grassroots reproductive health workers' generating indicators, followed by refinement and prioritization of these indicators through a consensus-building Delphi process among nationally and internationally known reproductive health experts. To generate these indicators, we sequenced two participatory techniques known as nominal group process and Delphi survey methodology. All rights reserved.We report community-based development of reproductive health indicators for China's rural areas. nucleatum and succinic acid induce tumor resistance to immunotherapy, offering insights into microbiota-metabolite-immune crosstalk in CRC.įusobacterium nucleatum cGAS-IFN-β pathway colorectal cancer immunotherapy succinic acid.Ĭopyright © 2023 Elsevier Inc. nucleatum abundance, thereby decreasing serum succinic acid levels and resensitizing tumors to immunotherapy in vivo. Treatment with the antibiotic metronidazole reduced intestinal F. nucleatum-derived succinic acid suppressed the cGAS-interferon-β pathway, consequently dampening the antitumor response by limiting CD8 + T cell trafficking to the tumor microenvironment (TME) in vivo. Author links open overlay panel Zhenqiang Wang a b, Yulong Gong a, Lin Zhang a, Chuan Jing a, Fang Gao a c, Shengtao Zhang a c, Hongru Li a c. nucleatum-high non-responders, conferred sensitivity to anti-PD-1 mAb in mice. Fecal microbiota transfer from responders with low F. We found that patients with metastatic CRC who fail to respond to immunotherapy had a greater abundance of Fusobacterium nucleatum and increased succinic acid. The gut microbiota has been linked to immunotherapy resistance through unclear mechanisms. However, some patients remain unresponsive to PD-1 blockade. Electronic address: checkpoint blockade therapy with anti-PD-1 monoclonal antibody (mAb) is a treatment for colorectal cancer (CRC). Feng explains the classical understanding of the Zhang Zhong Jing system, bringing you the knowledge of a Jing Fang. Electronic address: 6 Division of Gastroenterology and Hepatology, Shanghai Institute of Digestive Disease, NHC Key Laboratory of Digestive Diseases, State Key Laboratory for Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 145 Middle Shandong Road, Shanghai 200001, China.
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